Current location:Home > Pharmaceutical
Product
3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER
- CAS No.: 769195-26-8
- Purity: 99%
Quality products?make an important contribution to long-term revenue and profitability. Cost-effective and customizable 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER 769195-26-8 supplier
1.What is the 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER ?
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate is a useful synthetic intermediate in the synthesis of Sitagliptin (S491000); a trizolopyrazine dipeptidyl peptidase (DPP) IV inhibitor for the treatment of type II diabetes.
-
-
38330-80-2
monomethyl monopotassium malonate
-
-
209995-38-0
(2,4,5-trifluorophenyl)acetic acid
-
-
769195-26-8
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
| Conditions | Yield |
|---|---|
|
(2,4,5-trifluorophenyl)acetic acid;
With
1,1'-carbonyldiimidazole;
In
acetonitrile;
for 3.5h;
monomethyl monopotassium malonate;
With
triethylamine; magnesium chloride;
In
acetonitrile;
at 50 ℃;
for 8h;
In
acetonitrile;
at 30 ℃;
for 26h;
|
84%
|
|
monomethyl monopotassium malonate;
With
triethylamine;
In
acetonitrile;
at 30 - 50 ℃;
for 8.3h;
(2,4,5-trifluorophenyl)acetic acid;
With
1,1'-carbonyldiimidazole;
In
acetonitrile;
at 30 ℃;
for 3.5h;
|
83%
|
|
monomethyl monopotassium malonate;
With
triethylamine; magnesium chloride;
In
acetonitrile;
at 30 - 50 ℃;
Inert atmosphere;
(2,4,5-trifluorophenyl)acetic acid;
With
1,1'-carbonyldiimidazole;
In
acetonitrile;
at 30 ℃;
for 5.5h;
Inert atmosphere;
|
83%
|
-
-
1176895-65-0
2-(2,4,5-trifluorophenyl)acetyl chloride
-
-
96-32-2
bromoacetic acid methyl ester
-
-
769195-26-8
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester
| Conditions | Yield |
|---|---|
|
bromoacetic acid methyl ester;
With
iodine; magnesium;
In
tetrahydrofuran;
at 45 - 50 ℃;
Inert atmosphere;
2-(2,4,5-trifluorophenyl)acetyl chloride;
With
copper(l) iodide;
In
tetrahydrofuran;
at -20 - 5 ℃;
Inert atmosphere;
|
91%
|
2.What is the CAS number for 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER ?
The CAS number of 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER is 769195-26-8.
More information of 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER 769195-26-8 are:
|
CAS?Number |
769195-26-8 |
|
Density |
1.331 g/cm3 |
|
Melting Point |
40-41 °C |
|
Boiling Point |
273.265 °C at 760 mmHg |
|
Flash Point |
115.458 °C |
|
Refractive Index |
1.469 |
|
HS CODE |
2918300090 |
|
PSA |
43.37000 |
|
LogP |
1.77860 |
|
Pka |
9.95±0.46(Predicted) |
3.What are another words for 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER ?
Synonyms?for?3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER 769195-26-8:methyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
4.What is the molecular formula of 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER?
The chemical formula of ?3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER is?C11H9F3O3 which containing 11 Carbon atoms,9 Hydrogen atoms,3 Fluorine atoms and 3 Oxygen atoms,and the molecular weight of??3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER?is 246.186.
5.What is 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER (769195-26-8) used for?
3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER, also known as Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate, is a synthetic intermediate with significant applications in the pharmaceutical industry. It is characterized by its unique chemical structure, which features a trifluorophenyl group attached to a butyric acid methyl ester moiety. 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER plays a crucial role in the synthesis of various pharmaceutical compounds, particularly Sitagliptin.
Relevant articles related to 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER:
|
Article |
Source |
|
SITAGLIPTIN, SALTS AND POLYMORPHS THEREOF |
- Paragraph 0156; 0157; 0158; 0159; 0160, (2013/06/28) |
|
PROCESSES FOR THE PREPARATION OF R-SITAGLIPTIN AND INTERMEDIATES THEREOF |
- Page/Page column 27, (2012/04/17) |
6.Buy 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER with the best price .
Jiangxi Nanchang Feihongjia Chemicals Co., Ltd is a quality supplier of 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on 3-OXO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID METHYL ESTER 769195-26-8.
