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Argatroban

  • CAS No.: 74863-84-6
  • Purity: 99%
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1.What is the Argatroban ?

Argatroban is a reversible inhibitor of thrombin (IC50s = 0.01 and 0.09 μM for the free and clot-bound forms, respectively). It is selective for thrombin over factor Xa, trypsin, plasmin, and tissue plasminogen activator (Kis = 0.0045, 53, 0.19, 25.7, and 87.7 μM, respectively). It inhibits thrombin-induced platelet aggregation in washed isolated guinea pig platelets with an IC50 value of 0.077 μM. Argatroban (3.2 mg/kg, s.c.) decreases thrombus formation in a guinea pig model of iron chloride-induced arterial thrombosis. Formulations containing argatroban have been used in the prevention or treatment of thrombosis in patients with heparin-induced thrombocytopenia.

2.What is the CAS number for Argatroban ?

The CAS number of Argatroban is 74863-84-6.

3.What are another words for Argatroban ?

Synonyms?for?Argatroban 74863-84-6:2-Piperidinecarboxylicacid,1-[5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-,[2R-[1(2S*),2a,4b]]-[partial]-;Acova;Argatra;Argipidin;Argipidine;DK 7419;GN 1600;MCI 9038;MD 805;MQPA;Novastan;OM 805;Slonnon;

4.What is Argatroban (74863-84-6) used for?

(2S,4S)-1-(2R)-Argatroban is an isomeric impurity of Argatroban (74863-84-6 #CAS), which is a synthetic thrombin inhibitor. Antithrombotic.

InChI:InChI=1/C23H36N6O5S/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26)/t14-,15?,17-,18-/m0/s1

Relevant articles related to Argatroban:

Article

Source

Efficient Diastereoselective Three-Component Synthesis of Pipecolic Amides

van der Heijden, Gydo,van Schaik, Timo B.,Mouarrawis, Valentinos,de Wit, Martin J. M.,Velde, Christophe M. L. Vande,Ruijter, Eelco,Orru, Romano V. A.

, p. 5313 - 5325 (2019/06/10)

A short synthesis of argatroban: A potent selective thrombin inhibitor

Cossy, Janine,Belotti, Damien

, p. 1989 - 1992 (2007/10/03)

METHOD FOR INHIBITING THROMBOSIS

-

, (2008/06/13)

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